Seminars in Roentgenology
Volume 43, Issue 3 , Pages 193-203 , July 2008

Cardiac Magnetic Resonance Evaluation of Myocardial Viability and Ischemia

  • Jacek Strzelczyk, MD
    • ,
  • Anil Attili, FRCR

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Anil Attili, FRCR, Assistant Professor of Radiology, Department of Radiology, MRI/CT, University of Michigan Health Systems, 4260 Plymouth Rd., Room 1847, Ann Arbor, MI 48109-2713.

References 

  1. Yusuf S, Reddy S, Ounpuu S, et al. Global burden of cardiovascular diseases: Part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104(22):2746–2753
  2. Rosamond W, Flegal K, Friday G, et al. Heart disease and stroke statistics—2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007;115(5):e69–e171
  3. Nesto RW, Kowalchuk GJ. The ischemic cascade: temporal sequence of hemodynamic, electrocardiographic and symptomatic expressions of ischemia. Am J Cardiol. 1987;59(7):C23–C30
  4. Prasad SKLJ, Chai P, Gatehouse P. Role of CMR in assessment of myocardial perfusion. Eur Radiol. 2005;15(suppl 2):B42–B47
  5. Bax JJ, Visser FC, Poldermans D, et al. Time course of functional recovery of stunned and hibernating segments after surgical revascularization. Circulation. 2001;104(90001):I314–I318
  6. Gowda RM, Khan IA, Vasavada BC, et al. Reversible myocardial dysfunction: basics and evaluation. Int J Cardiol. 2004;97(3):349–353
  7. Bello D, Fieno DS, Kim RJ, et al. Infarct morphology identifies patients with substrate for sustained ventricular tachycardia. J Am Coll Cardiol. 2005;45(7):1104–1108
  8. Kim RJ, Fieno DS, Parrish TB, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation. 1999;100(19):1992–2002
  9. Fieno DS, Kim RJ, Chen E-L, et al. Contrast-enhanced magnetic resonance imaging of myocardium at risk: distinction between reversible and irreversible injury throughout infarct healing. J Am Coll Cardiol. 2000;36(6):1985–1991
  10. Peukert D, Laule M, Taupitz M, et al. 3D and 2D delayed-enhancement magnetic resonance imaging for detection of myocardial infarction: preclinical and clinical results. Acad Radiol. 2007;14(7):788–794
  11. Ovize MRD, de Lorgeril M, Pichard JB, et al. Quantitation of reperfused myocardial infarction by Gd-DOTA-enhanced magnetic resonance imaging (An experimental study). Invest Radiol. 1991;26(12):1065–1070
  12. Schulz-Menger J, Gross M, Messroghli D, et al. Cardiovascular magnetic resonance of acute myocardial infarction at a very early stage. J Am Coll Cardiol. 2003;42(3):513–518
  13. Simonetti OP, Kim RJ, Fieno DS, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology. 2001;218(1):215–223
  14. Gupta A, Lee VS, Chung Y-C, et al. Myocardial infarction: optimization of inversion times at delayed contrast-enhanced MR imaging. Radiology. 2004;233(3):921–926
  15. Kellman P, Arai AE. Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn Reson Med. 2002;47(2):372–383
  16. Kim RJ, Wu E, Rafael A, et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med. 2000;343(20):1445–1453
  17. Beek AM, Kuhl HP, Bondarenko O, et al. Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. J Am Coll Cardiol. 2003;42(5):895–901
  18. Biagini E, van Geuns RJ, Baks T, et al. Comparison between contrast echocardiography and magnetic resonance imaging to predict improvement of myocardial function after primary coronary intervention. Am J Cardiol. 2006;97(3):361–366
  19. Gerber BL, Garot J, Bluemke DA, et al. Accuracy of contrast-enhanced magnetic resonance imaging in predicting improvement of regional myocardial function in patients after acute myocardial infarction. Circulation. 2002;106(9):1083–1089
  20. Selvanayagam JB, Kardos A, Francis JM, et al. Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after surgical revascularization. Circulation. 2004;110(12):1535–1541
  21. Choi KM, Kim RJ, Gubernikoff G, et al. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation. 2001;104(10):1101–1107
  22. Hombach V, Grebe O, Merkle N, et al. Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging. Eur Heart J. 2005;26(6):549–557
  23. Bello D, Shah DJ, Farah GM, et al. Gadolinium cardiovascular magnetic resonance predicts reversible myocardial dysfunction and remodeling in patients with heart failure undergoing beta-blocker therapy. Circulation. 2003;108(16):1945–1953
  24. Kwong RY, Chan AK, Brown KA, et al. Impact of unrecognized myocardial scar detected by cardiac magnetic resonance imaging on event-free survival in patients presenting with signs or symptoms of coronary artery disease. Circulation. 2006;113(23):2733–2743
  25. Yan AT, Shayne AJ, Brown KA, et al. Characterization of the peri-infarct zone by contrast-enhanced cardiac magnetic resonance imaging is a powerful predictor of post-myocardial infarction mortality. Circulation. 2006;114(1):32–39
  26. Lim RP, Srichai MB, Lee VS. Non-ischemic causes of delayed myocardial hyperenhancement on MRI. AJR Am J Roentgenol. 2007;188(6):1675–1681
  27. Klein C, Nekolla SG, Bengel FM, et al. Assessment of myocardial viability with contrast-enhanced magnetic resonance imaging: comparison with positron emission tomography. Circulation. 2002;105(2):162–167
  28. Wagner A, Mahrholdt H, Holly TA, et al. Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003;61(9355):374–379
  29. Lund GK, Stork A, Saeed M, et al. Acute myocardial infarction: evaluation with first-pass enhancement and delayed enhancement MR imaging compared with 201Tl SPECT imaging. Radiology. 2004;232(1):49–57
  30. Gutberlet MFM, Mehl S, Amthauer H, et al. Myocardial viability assessment in patients with highly impaired left ventricular function: comparison of delayed enhancement, dobutamine stress MRI, end-diastolic wall thickness, and TI201-SPECT with functional recovery after revascularization. Eur Radiol. 2005;15(5):872–880
  31. Hendel RC, Jamil T, Glover DK. Pharmacologic stress testing: new methods and new agents. J Nucl Cardiol. 2003;10(2):197–204
  32. Tulevski , van der Wall EE, Groenink M, et al. Usefulness of magnetic resonance imaging dobutamine stress in asymptomatic and minimally symptomatic patients with decreased cardiac reserve from congenital heart disease (complete and corrected transposition of the great arteries and subpulmonic obstruction). Am J Cardiol. 2002;89(9):1077–1081
  33. Dymarkowski SSM, Maes A, Liu XS, et al. Assessment of myocardial viability in a porcine model of chronic coronary artery stenosis with dual dose dobutamine magnetic resonance imaging. Int J Cardiovasc Imaging. 2003;19(1):63–72
  34. Kuijpers DJC, van Dijkman PR, Oudkerk M. Dobutamine stress MRI. Part I. Safety and feasibility of dobutamine cardiovascular magnetic resonance in patients suspected of myocardial ischemia. Eur Radiol. 2004;14(10):1823–1828
  35. Raman S. Dobutamine stress magnetic resonance imaging. Emerg Radiol. 2002;9(5):289–291
  36. Muehling OMHA, Friedrich D, Nabauer M, et al. Code blue in the MR suite—a drill to rescue a patients with cardiac arrest from the MR scanner. Int J Cardiovasc Imaging. 2006;22(2):257–261
  37. Miyamoto MI, Vernotico SL, Majmundar H, et al. Pharmacologic stress myocardial perfusion imaging: a practical approach. J Nucl Cardiol. 2007;14(2):250–255
  38. Dendale P, Franken PR, Holman E, et al. Validation of low-dose dobutamine magnetic resonance imaging for assessment of myocardial viability after infarction by serial imaging. Am J Cardiol. 1998;82(3):375–377
  39. Geskin G, Kramer CM, Rogers WJ, et al. Quantitative assessment of myocardial viability after infarction by dobutamine magnetic resonance tagging. Circulation. 1998;98(3):217–223
  40. Sandstede JJW, Bertsch G, Beer M, et al. Detection of myocardial viability by low-dose dobutamine cine MR imaging. Magn Reson Imaging. 1999;17(10):1437–1443
  41. Rerkpattanapipat P, Little WC, Clark HP, et al. Effect of the transmural extent of myocardial scar on left ventricular systolic wall thickening during intravenous dobutamine administration. Am J Cardiol. 2005;95(4):495–498
  42. Wellnhofer E, Olariu A, Klein C, et al. Magnetic resonance low-dose dobutamine test is superior to scar quantification for the prediction of functional recovery. Circulation. 2004;109(18):2172–2174
  43. Bove CM, DiMaria JM, Voros S, et al. Dobutamine response and myocardial infarct transmurality: functional improvement after coronary artery bypass grafting—initial experience. Radiology. 2006;240(3):835–841
  44. Paetsch I, Jahnke C, Wahl A, et al. Comparison of dobutamine stress magnetic resonance, adenosine stress magnetic resonance, and adenosine stress magnetic resonance perfusion. Circulation. 2004;110(7):835–842
  45. van Dijkman PRM, Kuijpers DA, Blom BM, et al. Dobutamine stress magnetic resonance imaging: a valuable method in the noninvasive diagnosis of ischemic heart disease. J Electrocardiol. 2002;35(4 Pt 2):57–59
  46. Nagel E, Lehmkuhl HB, Bocksch W, et al. Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation. 1999;99(6):763–770
  47. Nandalur KR, Dwamena BA, Choudhri AF, et al. Diagnostic performance of stress cardiac magnetic resonance imaging in the detection of coronary artery disease: a meta-analysis. J Am Coll Cardiol. 2007;50(14):1343–1353
  48. Hundley WG, Hamilton CA, Thomas MS, et al. Utility of fast cine magnetic resonance imaging and display for the detection of myocardial ischemia in patients not well suited for second harmonic stress echocardiography. Circulation. 1999;100(16):1697–1702
  49. Hundley WG, Morgan TM, Neagle CM, et al. Magnetic resonance imaging determination of cardiac prognosis. Circulation. 2002;106(18):2328–2333
  50. Jahnke C, Nagel E, Gebker R, et al. Prognostic value of cardiac magnetic resonance stress tests: adenosine stress perfusion and dobutamine stress wall motion imaging. Circulation. 2007;115(13):1769–1776
  51. Syed MA, Paterson DI, Ingkanisorn WP, et al. Reproducibility and inter-observer variability of dobutamine stress CMR in patients with severe coronary disease: implications for clinical research. J Cardiovasc Magn Reson. 2005;7(5):763–768
  52. Paetsch I, Jahnke C, Ferrari VA, et al. Determination of interobserver variability for identifying inducible left ventricular wall motion abnormalities during dobutamine stress magnetic resonance imaging. Eur Heart J. 2006;27(12):1459–1464
  53. Kuijpers D, Ho KY, van Dijkman PR, et al. Dobutamine cardiovascular magnetic resonance for the detection of myocardial ischemia with the use of myocardial tagging. Circulation. 2003;107(12):1592–1597
  54. White MP. Pharmacologic stress testing: understanding the options. J Nucl Cardiol. 1999;6(6):672–675
  55. Cerqueira MD, Verani MS, Schwaiger M, et al. Safety profile of adenosine stress perfusion imaging: results from the Adenoscan Multicenter Trial Registry. J Am Coll Cardiol. 1994;23(2):384–389
  56. Gebker R, Schwitter J, Fleck E, et al. How we perform myocardial perfusion with cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2007;9(3):539–547
  57. Kim HW, Klem I, Kim RJ. Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance. Cardiol Clin. 2007;25(1):57–70vi
  58. Klem I, Heitner JF, Shah DJ, et al. Improved detection of coronary artery disease by stress perfusion cardiovascular magnetic resonance with the use of delayed enhancement infarction imaging. J Am Coll Cardiol. 2006;47(8):1630–1638
  59. Futamatsu HKC, Pilla M, Wilke N, et al. Diagnostic accuracy of quantitative cardiac MRI evaluation compared to stress single-photon-emission computed tomography. Int J Cardiovasc Imaging. 2007;Sep 11 (Epub ahead of print)
  60. Fenchel M, Helber U, Kramer U, et al. Detection of regional myocardial perfusion deficit using rest and stress perfusion MRI: a feasibility study. AJR Am J Roentgenol. 2005;185(3):627–635
  61. Plein S, Radjenovic A, Ridgway JP, et al. Coronary artery disease: myocardial perfusion mr imaging with sensitivity encoding versus conventional angiography. Radiology. 2005;235(2):423–430
  62. Al-Saadi N, Nagel E, Gross M, et al. Noninvasive detection of myocardial ischemia from perfusion reserve based on cardiovascular magnetic resonance. Circulation. 2000;101(12):1379–1383
  63. Chiu CW, So NM, Lam WW, et al. Combined first-pass perfusion and viability study at MR imaging in patients with non-ST segment-elevation acute coronary syndromes: feasibility study. Radiology. 2003;226(3):717–722
  64. Doyle M, Fuisz A, Kortright E, et al. The impact of myocardial flow reserve on the detection of coronary artery disease by perfusion imaging methods: an NHLBI WISE study. J Cardiovasc Magn Reson. 2003;5(3):475–485
  65. Giang TH, Nanz D, Coulden R, et al. Detection of coronary artery disease by magnetic resonance myocardial perfusion imaging with various contrast medium doses: first European multi-centre experience. Eur Heart J. 2004;25(18):1657–1665
  66. Ibrahim T, Nekolla SG, Schreiber K, et al. Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography. J Am Coll Cardiol. 2002;39(5):864–870
  67. Ishida N, Sakuma H, Motoyasu M, et al. Noninfarcted myocardium: correlation between dynamic first-pass contrast-enhanced myocardial MR imaging and quantitative coronary angiography. Radiology. 2003;229(1):209–216
  68. Klein MA, Collier BD, Hellman RS, et al. Detection of chronic coronary artery disease: value of pharmacologically stressed, dynamically enhanced turbo-fast low-angle shot MR images. AJR Am J Roentgenol. 1993;161(2):257–263
  69. Nagel E, Klein C, Paetsch I, et al. Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation. 2003;108(4):432–437
  70. Paetsch I, Jahnke C, Wahl A, et al. Comparison of dobutamine stress magnetic resonance, adenosine stress magnetic resonance, and adenosine stress magnetic resonance perfusion. Circulation. 2004;110(7):835–842
  71. Panting JR, Gatehouse PD, Yang GZ, et al. Echo-planar magnetic resonance myocardial perfusion imaging: parametric map analysis and comparison with thallium SPECT. J Magn Reson Imaging. 2001;13(2):192–200
  72. Plein S, Greenwood JP, Ridgway JP, et al. Assessment of non-ST-segment elevation acute coronary syndromes with cardiac magnetic resonance imaging. J AmColl Cardiol. 2004;44(11):2173–2181
  73. Plein S, Radjenovic A, Ridgway JP, et al. Coronary artery disease: myocardial perfusion MR imaging with sensitivity encoding versus conventional angiography. Radiology. 2005;235(2):423–430
  74. Schwitter J, Nanz D, Kneifel S, et al. Assessment of myocardial perfusion in coronary artery disease by magnetic resonance: a comparison with positron emission tomography and coronary angiography. Circulation. 2001;103(18):2230–2235
  75. Sensky PR, Samani NJ, Reek C, et al. Magnetic resonance perfusion imaging in patients with coronary artery disease: a qualitative approach. Int J Cardiovasc Imaging. 2002;18(5):373–383discussion 385-376
  76. Wolff SD, Schwitter J, Coulden R, et al. Myocardial first-pass perfusion magnetic resonance imaging: a multicenter dose-ranging study. Circulation. 2004;110(6):732–737
  77. Panting JR, Gatehouse PD, Yang GZ. Echo-planar magnetic resonance myocardial perfusion imaging: parametric map analysis and comparison with thallium SPECT. J Magn Reson Imaging. 2001;13(2):192–200
  78. Beller GA, Zaret BL. Contributions of nuclear cardiology to diagnosis and prognosis of patients with coronary artery disease. Circulation. 2000;101(12):1465–1478
  79. Ingkanisorn WP, Kwong RY, Bohme NS, et al. Prognosis of negative adenosine stress magnetic resonance in patients presenting to an emergency department with chest pain. J AmColl Cardiol. 2006;47(7):1427–1432
  80. Hendel RC, Patel MR, Kramer CM, et al. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 Appropriateness Criteria for Cardiac Computed Tomography and Cardiac Magnetic Resonance Imaging: A Report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol. 2006;48(7):1475–1497
  81. Cury RC, Cattani CA, Gabure LA, et al. Diagnostic performance of stress perfusion and delayed-enhancement MR imaging in patients with coronary artery disease. Radiology. 2006;240(1):39–45

PII: S0037-198X(08)00027-8

doi: 10.1053/j.ro.2008.02.005

Seminars in Roentgenology
Volume 43, Issue 3 , Pages 193-203 , July 2008

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