Seminars in Roentgenology
Volume 40, Issue 1 , Pages 64-73 , January 2005

Approaches to CT perfusion imaging in pulmonary embolism

  • Joachim E. Wildberger, MD

      Affiliations

    • Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
    • Corresponding Author InformationAddress reprint requests to: Joachim Ernst Wildberger, MD, Department of Diagnostic Radiology, University Hospital, University of Technology (RWTH), Pauwelsstrasse 30, D-52074 Aachen, Germany.
    • ,
  • U. Joseph Schoepf, MD

      Affiliations

    • Department of Radiology, Medical University of South Carolina, Charleston, SC.
    • ,
  • Andreas H. Mahnken, MD

      Affiliations

    • Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
    • ,
  • Peter Herzog, MD

      Affiliations

    • Institute of Clinical Radiology, Ludwig Maximilians University, Munich, Germany.
    • ,
  • Hendrik Ditt, PhD

      Affiliations

    • Siemens Medical Solutions, Computed Tomography, Forchheim, Germany.
    • ,
  • Matthias U. Niethammer, PhD

      Affiliations

    • Siemens Medical Solutions, Computed Tomography, Forchheim, Germany.
    • ,
  • Stefan Schaller, PhD

      Affiliations

    • Siemens Medical Solutions, Computed Tomography, Forchheim, Germany.
    • ,
  • Ernst Klotz, PhD

      Affiliations

    • Siemens Medical Solutions, Computed Tomography, Forchheim, Germany.
    • ,
  • Rolf W. Günther, MD

      Affiliations

    • Department of Diagnostic Radiology, University of Technology, Aachen, Germany.

References 

  1. Schoepf UJ , Costello P . CT angiography for diagnosis of pulmonary embolism (state of the art) . Radiology . 2004;230:329–337
  2. Rémy-Jardin M , Baghaie F , Bonnel F , et al.   Thoracic helical CT (influence of subsecond scan time and thin collimation on evaluation of peripheral pulmonary arteries) . Eur Radiol . 2000;10:1297–1303
  3. Müller C , Kopka L , Funke M , et al.   Diagnosis of lung embolism and underlying venous thrombosis in multi-slice spiral CT . Fortschr Röntgenstr . 1999;170:542–549
  4. Ghaye B , Szapiro D , Mastora I , et al.   Peripheral pulmonary arteries (how far in the lung does multi-detector row spiral CT allow analysis?) . Radiology . 2001;219:629–636
  5. Schoepf UJ , Holzknecht N , Helmberger TK , et al.   Subsegmental pulmonary emboli (Improved detection with thin-collimation multi-detector row spiral CT) . Radiology . 2002;222:483–490
  6. Patel S , Kazerooni EA , Cascade PN . Pulmonary embolism (optimization of small pulmonary arteries visualization at multidetector row CT) . Radiology . 2003;227:455–460
  7. Klingenbeck-Regn K , Schaller S , Flohr T , et al.   Subsecond multi-slice computed tomography (basics and applications) . Eur J Radiol . 1999;31:110–124
  8. Remy-Jardin M , Tillie-Leblond I , Szapiro D , et al.   CT angiography of pulmonary embolism in patients with underlying respiratory disease (impact of multislice CT on image quality and negative predictive value) . Eur Radiol . 2002;12:1971–1978
  9. British Thoracic Society Standards of Care Committee Pulmonary Embolism Guideline Development Group . British Thoracic Society guidelines for the management in suspected acute pulmonary embolism . Thorax . 2003;58:470–484
  10. Goldhaber SZ , Elliot CG . Acute pulmonary embolism: Part I. Epidemiology, pathophysiology, and diagnosis . Circulation . 2003;108:2726–2729
  11. Wintersperger BJ , Stäbler A , Seemann M , et al.   Evaluation of right ventricular performance in patients with acute pulmonary embolism by helical CT . Fortschr Röntgenstr . 1999;170:542–549
  12. Reid JH , Murchison JT . Acute right ventricular dilatation (a new helical CT sign of massive pulmonary embolism) . Clin Radiol . 1998;53:694–698
  13. Oliver TB , Reid JH , Murchison JT . Interventricular septal shift due to massive pulmonary embolism shown by CT pulmonary angiography (an old sign revisited) . Thorax . 1998;53:1092–1094
  14. Carson JL , Kelley MA , Duff A , et al.   The clinical course of pulmonary embolism . N Engl J Med . 1992;326:1240–1245
  15. Bankier AA , Janata K , Fleischmann D , et al.   Severity assessment of acute pulmonary embolism with spiral CT (evaluation of two modified angiographic scores and comparison with clinical data) . J Thorac Imaging . 1997;12:150–158
  16. Mastora I , Remy-Jardin M , Masson P , et al.   Severity of acute pulmonary embolism (evaluation of a new spiral CT angiographic score in correlation with echocardiographic data) . Eur Radiol . 2003;13:29–35
  17. Qanadli SD , El Hajjam M , Vieillard-Baron A , et al.   New CT index to quantify arterial obstruction in pulmonary embolism (comparison with angiographic index and echocardiography) . Am J Roentgenol . 2001;176:1415–1420
  18. Amundsen T , Kvaerness J , Jones R , et al.   Pulmonary embolism (detection with MR perfusion imaging of lung, a feasibilty study) . Radiology . 1997;203:181–185
  19. Reittner P , Coxson HO , Nakano Y , et al.   Pulmonary embolism (comparison of Gadolinium-enhanced MR angiography with contrast-enhanced spiral CT in an porcine model) . Acad Radiol . 2001;8:343–350
  20. The PIOPED investigators . Value of the ventilation-perfusion scan in acute pulmonary embolism (result of the prospective investigation of pulmonary embolism) . J Am Med Assoc . 1990;263:2753–2759
  21. Wolfkiel CJ , Rich S . Analysis of regional pulmonary enhancement in dogs by ultrafast computed tomography . Invest Radiol . 1992;27:211–216
  22. Screaton NJ , Coxson HO , Kalloger SE , et al.   Detection of lung perfusion abnormalities using computed tomography in a porcine model of pulmonary embolism . J Thorac Imaging . 2003;18:14–20
  23. Hoffman EA , Tajik JK , Kugelmass SD . Matching pulmonary structure and perfusion via combined dynamic multislice CT and thin-slice high-resolution CT . Comp Med Imag Graph . 1995;19:101–112
  24. Groell R , Peichel KH , Uggowitzer MM , et al.   Computed tomography densitometry of the lung (a method to assess perfusion defects in acute pulmonary embolism) . Eur J Radiol . 1999;32:192–196
  25. Kalender WA , Rienmüller R , Seissler W , et al.   Measurement of pulmonary parenchymal attenuation (use of spirometric gating with quantitative CT) . Radiology . 1990;175:265–268
  26. Stanford W , Rooholamini SA , Galvin JR . Ultrafast computed tomography in the detection of intracardiac masses and pulmonary artery thrombembolism . In:  Stanford WRJ editors. Ultrafast Computed Tomography in Cardiac Imaging (Principles and Practice) . Mount Kisco, NY: Futura Publishing; 1992;p. 235–249
  27. Schoepf UJ , Bruening R , Konschitzky H , et al.   Pulmonary embolism (comprehensive diagnosis by using electron-beam CT for detection of emboli and assessment of pulmonary blood flow) . Radiology . 2000;217:693–700
  28. Coulden RA , Brown SJ , Clements L , et al.   Mosaic perfusion in pulmonary hypertension (how does multislice CT compare with perfusion scintigraphy) . Radiology . 2000;217:S384–S385
  29. Wildberger JE , Mahnken AH , Sinha AM , et al.   A differentiated approach to the diagnosis of pulmonary embolism and deep venous thrombosis using multi-slice CT . Fortschr Röntgenstr . 2002;174:301–307
  30. Wildberger JE , Niethammer MU , Klotz E , et al.   Multi-slice CT for visualization of pulmonary embolism using perfusion weighted color maps . Fortschr Röntgenstr . 2001;173:289–294
  31. Herzog P , Wildberger JE , Niethammer MU , et al.   CT perfusion imaging of the lung in pulmonary embolism . Acad Radiol . 2003;10:1132–1146
  32. Wildberger JE , Mahnken AH , Ditt H , et al.   Single breath-hold subtraction (novel approach to diagnosing pulmonary embolism by multi-slice CT—work in progress) . Eur Radiol . 2004;14:S536–S537

PII: S0037-198X(04)00107-5

doi: 10.1053/j.ro.2004.09.006

Seminars in Roentgenology
Volume 40, Issue 1 , Pages 64-73 , January 2005

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